JAK the trigger

JAK-STAT pathway and JAK inhibitors: a primer for dermatologists

Background: All cellular events depend upon the DNA synthesis and gene expression involving complex interplay between ligands such as interleukins and interferons, with various cell membrane receptors. These ligand-receptors interactions transmit signals within the cell via numerous signal transduction pathways to affect gene expression. Janus kinase/signal transducer and activator of transcrip...

EGFR and JAK/STAT, which act upstream of Notch to trigger proliferation and promote enterocyte survival in the midgut (Jiang

INTRODUCTION To compensate for cell loss, most animal tissues maintain slowly proliferating populations of stem cells that are able to differentiate on demand. Given the great potential of stem cells for the management of many human diseases, it is important to understand in detail the molecular pathways that control the biology of stem cells, including their origin, pattern of proliferation an...

The Jak/STAT pathway.

Cellular responses to dozens of cytokines and growth factors are mediated by the evolutionarily conserved Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway (Fig. 1). These responses include proliferation, differentiation, migration, apoptosis, and cell survival, depending on the signal, tissue, and cellular context. JAK/STATsignaling is essential for n...

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

The Luteal Phase after GnRHa Trigger-Understanding An Enigma